Listeria-based and llo-based vaccines

Details Listeria-based and llo-based vaccines Listeria-based and llo-based vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2581331

This invention provides methods of treating and vaccinating against an antigen- expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strains expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment used to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccine4s and immunogenic compositions comprising same, and methods of inducing an Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.

Cette invention concerne des méthodes de traitement d'une tumeur exprimant un antigène, de vaccination contre cette tumeur et d'induction d'une réponse immunitaire contre un épitope sous-dominant de l'antigène, comprenant une fusion entre un fragment de LLO et l'antigène ou une souche de Listeria recombinante exprimant cet antigène. La présente invention concerne également des peptides recombinants comprenant un fragment protéique de listériolysine (LLO) fusionné à une protéine Her-2 ou un fragment de celle-ci, des souches de Listeria recombinantes exprimant une protéine Her-2, des vaccins et compositions immunogéniques contenant cette dernière ainsi que des méthodes d'induction d'une réponse immunitaire anti-Her-2, de traitement et de vaccination contre une tumeur exprimant l'Her-2.

Affiliated with

Also associated with

Rating

Listeria-based and llo-based vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Listeria-based and llo-based vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Listeria-based and llo-based vaccines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1466250