C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 39/002 (2006.01) C07K 14/245 (2006.01) C07K 14/435 (2006.01) C12N 1/10 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2498604
The present invention relates inter alia to attenuated live parasites of the phylum Apicomplexa and the family of Trypanosomatidae and to the use of such attenuated live parasites in a vaccine and in the manufacturing of such a vaccine. Furthermore, the present invention relates to vaccines comprising such attenuated live parasites and to methods for the production of such vaccines. Finally, the invention relates to specific tet-repressor fusion proteins and to attenuated live parasites according to the invention comprising such tet-repressor fusion proteins.
L'invention concerne, entre autres, des parasites vivants atténués du genre Apicomplexa et de la famille des Trypanosomatidae, ainsi que l'utilisation de ce type de parasite vivant atténué dans un vaccin et dans la fabrication d'un tel vaccin. Elle concerne encore des vaccins contenant de tels parasites vivants atténués et des procédés de production de ces vaccins. Elle concerne enfin des protéines de fusion spécifiques du répresseur tet et des parasites vivants atténués selon l'invention comprenant de telles protéines de fusion spécifiques du répresseur tet.
Schaap Theodorus Cornelis
Van Poppel Nicole Francisca Johanna
Vermeulen Arnoldus Nicolaas
Akzo Nobel N.v.
Fetherstonhaugh & Co.
Intervet International B.v.
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