Live, attentuated respiratory syncytial virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/08 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01)

Patent

CA 2742086

The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when administered to a subject but substantially retain the antigenic and immunogenic properties of wild-type RSV.

L'invention concerne un virus syncytial respiratoire (VSR) vivant atténué utile contre les infections par le VSR et/ou le développement de syndromes aigus associés au VSR. Ledit virus, atténué jusqu'à devenir non pathogène lorsqu'administré à un sujet, conserve néanmoins les propriétés antigènes et immunogènes du VSR de type sauvage.

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