A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2699367
The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuatedMycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.
La présente invention concerne des bactéries Mycoplasma vivantes atténuées qui présentent une expression réduite d'une ou plusieurs protéines choisies dans le groupe constitué de pyruvate déshydrogénase, phosphopyruvate hydratase, 2-désoxyribose-5-phosphate aldolase et protéine ribosomique L35, par rapport à une bactérie Mycoplasma de type sauvage de la même espèce. L'invention concerne également des vaccins et des procédés de vaccination impliquant l'utilisation de bactéries Mycoplasma vivantes atténuées et des procédés de fabrication de ces dernières.
Khan Muhammad Ayub
Kumar Mahesh
Torys Llp
Wyeth Llc
LandOfFree
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