Live attenuated salmonella vaccines to control avian pathogens

A - Human Necessities – 61 – K

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Details

A61K 39/112 (2006.01) A61K 39/116 (2006.01) C07K 14/245 (2006.01) C07K 14/255 (2006.01) C12N 15/30 (2006.01)

Patent

CA 2338555

A vaccine for protecting birds against infection by avian pathogenic gram negative microbes is disclosed. The vaccine is a recombinant Salmonella strain expressing O-antigen of an avian pathogenic gram negative microbe such as an E. coli strain that is pathogenic in poultry. The recombinant Salmonella strain also does not express Salmonella O-antigen. Methods of using the vaccine to immunize birds are also disclosed.

Vaccin servant à protéger des oiseaux contre une infection provoquée par des microbes pathogènes aviaires Gram-négatifs. Ce vaccin consiste en une souche de recombinaison de Salmonella exprimant l'O-antigène d'un microbe pathogène aviaire Gran-négatif, telle qu'une souche de E. coli pathogène pour la volaille. Cette souche de recombinaison de Salmonella n'exprime pas non plus l'O-antigène de Salmonella. Procédés servant à mettre ce vaccin en application afin d'immuniser des oiseaux.

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