C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/130, 195/33
C12N 7/08 (2006.01) A61K 39/215 (2006.01)
Patent
CA 1340017
The cold-adapted (ca) temperature-sensitive (ts) vaccine is prepared by serially passaging a suitably selected virus (e.g. Arkansas-type DPI strain) through a culture medium at a suboptimal replication temperature which is less than about 35°C, e.g. 28°C, and harvesting the live, cold-adapted mutant for formulation into dosage units of, for example, about 10 3 to about 10 5 EID50 /bird. The ca ts mutant is much less able to replicate at 40-42°C (internal avian body temperatures) than at the temperature of the bird's upper respiratory tract, which is below 40°C. The vaccine can be administered by any of the usual techniques, including the spray technique. Vaccines of this invention appear to be very effective (immunogenic), but are also safe (non-pathogenic).
589247
Cassan Maclean
The University Of Delaware
LandOfFree
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