Live recombinant avian vaccine using an avian herpesvirus as...

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A61K 39/245 (2006.01) A61K 39/295 (2006.01) C07K 14/055 (2006.01) C07K 14/125 (2006.01) C07K 14/165 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2166367

The live recombinant avian vaccine comprises, as vector, an avian herpesvirus comprising at least one nucleotide sequence coding for and expressing an antigenic polypeptide of an avian pathogenic agent, inserted into the region lying between the ATG of ORF UL55 and the junction of U L with the adjacent repeat region, under the control of the CMV immediate early promoter. The vector is preferably chosen from the group consisting of Marek's disease viruses (MDV and HVT), infectious laryngotracheitis virus ILTV and herpes of ducks. A polyvalent vaccine formula comprises at least two vaccines of this type, with different inserted sequences.

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