C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/145 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2423038
The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to adpative selection are minimized or prevented. The process does not require purification of the virus-containing supernatant harvested from the cell culture nor post-incubation treatment of the viruses for HA activation. The invention further relates to influenza A and B master strain candidates and to vaccines made thereof.
L'invention concerne un procédé simple et efficace pour isoler des virus à partir de sources variées et pour produire des vaccins antigrippaux vivants atténués dans une culture cellulaire Vero sans sérum dans des conditions permettant de minimiser ou de prévenir une altération des antigènes de surface du virus due à une sélection adaptative. Ce procédé ne nécessite pas de purification du surnageant contenant le virus, obtenu à partir de la culture cellulaire, ni de traitement de post-incubation des virus pour activation HA. L'invention concerne également des souches mères de grippes A et B candidates, ainsi que des vaccins produits à partir de ces souches.
Egorov Andre
Ferko Boris
Katinger Dietmar
Katinger Hermann
Romanova Julia
Gowling Lafleur Henderson Llp
Polymun Scientific Immunbiologische Forschung Gmbh
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