Live virus vaccines to protect primates from hiv-1 infection...

A - Human Necessities – 61 – K

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A61K 39/21 (2006.01) A61P 31/18 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2345959

The instant invention teaches pathogenic SHIV which cause AIDS in monkeys, the construction of virus for use in vaccines against pathogenic SHIV and HIV-1, and methods for prophylactic and therapeutic vaccination to prevent or inhibit HIV-1 infection and/or disease. The instant invention teaches the construction of modified live virus for use in vaccines against HIV-1, and methods for prophylactic and therapeutic vaccination to prevent or inhibit HIV-1 infection and/or disease. The instant invention teaches the use of viral DNA vaccines for the treatment and prevention of HIV infection and/or disease.

La présente invention concerne le SHIV pathogène à l'origine du SIDA chez les singes, l'élaboration d'un virus destiné à s'utiliser dans des vaccins contre le SHIV pathogène et le VIH-1, ainsi que des méthodes de vaccination thérapeutique et prophylactique de prévention ou d'inhibition d'infections et/ou de maladies dues au VIH-1. La présente invention concerne également l'élaboration d'un virus actif modifié destiné à s'utiliser dans des vaccins contre VIH-1, ainsi que des méthodes de vaccination prophylactique et thérapeutique de prévention ou d'inhibition d'infections et/ou de maladies dues au VIH-1. La présente invention concerne enfin l'utilisation de vaccins génétiques viraux destinés au traitement et à la prévention d'infections et/ou de maladies dues au VIH.

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