Liver cancer biomarkers

Details Liver cancer biomarkers Liver cancer biomarkers

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/04 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2544708

The invention relates to the identification and selection of biomarkers which demonstrate particular advantage in identifying individuals having liver cancer. The invention further relates to useful combinations of biomarkers for diagnosing liver cancer. The invention further provides for the polynucleotides and polypeptides and kits thereof for use as a tool to diagnose disease and to monitor the efficacy of therapeutic regimens. The invention further provides a method of selecting biomarker combinations and the combinations thus identified for diagnosis of liver cancer. Also encompassed by the invention are screening methods to identify therapeutic targets for treating liver cancer, and identify single nucleotide point mutations related to liver cancer.

L'invention concerne l'identification et la sélection de biomarqueurs présentant un avantage spécifique dans l'identification d'individus souffrant du cancer du foie. L'invention concerne également des combinaisons utiles de biomarqueurs permettant de diagnostiquer le cancer du foie. L'invention concerne, en outre, des polynucléotides et des polypeptides, ainsi que des kits de ceux-ci à utiliser comme outil pour diagnostiquer une maladie et pour surveiller l'efficacité de régimes thérapeutiques. L'invention concerne un procédé de sélection de combinaisons de biomarqueurs et les combinaisons ainsi identifiées pour le diagnostic du cancer du foie. L'invention concerne enfin des procédés de criblage permettant d'identifier des cibles thérapeutiques permettant de traiter le cancer du foie et des mutations ponctuelles nucléotidiques uniques relatives au cancer du foie.

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