Liver progenitor cells

Details Liver progenitor cells Liver progenitor cells

C - Chemistry, Metallurgy

12

N

C12N 5/22 (2006.01)

Patent

CA 2609523

The invention relates to human liver pluripotent progenitor cell lines which express hepatic cell markers such as albumin and .alpha.-fetoprotein and do not express some of the markers which are typical of oval stem cells. Also disclosed is a method of isolating the cell lines of the invention, methods for differentiating said cells into a plurality of different cell lineages, methods for conditional immortalization and metabolic selection of said cells, as well as the use of the cell lines of the invention for preparing a medicament with osteogenic differentiation activity or liver injury regeneration activity.

L'invention porte sur des lignes cellulaires progénitrices pluripotentes du foie humain, qui expriment des marqueurs de cellules hépatiques tels que l'albumine et .alpha.-fetoprotéine et n'expriment pas certains marqueurs qui sont propres aux cellules souches ovales. L'invention porte aussi sur un procédé d'isolement des lignes cellulaires de l'invention, sur des procédés de différentiation de ces cellules parmi une pluralité de lignées cellulaires différentes, sur des procédés d'immortalisation conditionnelle et de sélection métabolique desdites cellules, ainsi que sur l'utilisation des lignes cellulaires de l'invention dans la préparation d'un médicament par activité de différentiation ostéogénique ou par activité de régénération d'une lésion du foie.

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