Liver retention clearing agents

Details Liver retention clearing agents Liver retention clearing agents

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2257353

Liver retention clearing agents (LRCAs) and the use thereof are discussed. LRCAs are composed of a hepatic clearance directing component which directs the biodistribution of a LRCA-containing construct to hepatic clearance; a binding component which mediates binding of the LRCA to a compound for which rapid hepatic clearance is desired; a liver retention component which diminishes access of binding component-containing metabolites to target sites; and a structural component to provide a scaffold for the other components.

L'invention concerne des agents de suppression de la rétention hépatique et leur utilisation. Ces agents sont composés d'un composant assurant la clairance hépatique qui dirige la biodistribution d'un produit de recombinaison contenant des agents de suppression de la rétention hépatique de manière à assurer la clairance hépatique. Ces agents comprennent également un composant de liaison qui assure la liaison de l'agent à un composé pour lequel une clairance hépatique rapide doit être assurée, et un composant de rétention hépatique qui diminue l'accès aux sites cibles des métabolites contenant un composant de liaison, et enfin un composant structurel constituant un squelette pour les autres composants.

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