Liver-specific adenovirus expression vector

Details Liver-specific adenovirus expression vector Liver-specific adenovirus expression vector

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C12N 15/12 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2226926

The invention concerns an adenovirus vector for the liver-specific gene therapy, fields of application in medicine are the treatment of gene defects and tumour diseases of the liver and molecular biology. The vector according to the invention is marked by the fact that a therapeutic gene which is coupled with a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancerless minimum promoter and is surrounded by SAR elements, in the case of need, is inserted into the adenovirus genom.

L'invention concerne un vecteur d'adénovirus destiné à la thérapie génétique hépato-spécifique. Les domaines d'application englobent, en médecine, le traitement des défauts génétiques et des affections tumorales du foie, ainsi que la biologie moléculaire. Ce vecteur est caractérisé en ce qu'un gène thérapeutique couplé à un promoteur hépato-spécifique constitué d'éléments activateurs du virus de l'hépatite B et d'un promoteur minimal sans activateur, et éventuellement entouré d'éléments SAR, est inséré dans le génome de l'adénovirus.

Affiliated with

Also associated with

Rating

Liver-specific adenovirus expression vector does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liver-specific adenovirus expression vector, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liver-specific adenovirus expression vector will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1376772