Liver stromal cells for prevention and treatment of immune...

A - Human Necessities – 01 – N

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A01N 63/00 (2006.01)

Patent

CA 2579835

The present invention encompasses methods and compositions for reducing an immune response to a transplant in a recipient by treating said recipient with an amount of liver stromal cells effective to reduce or inhibit host rejection of the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with liver stromal cells.

L'invention concerne des méthodes et des compositions permettant de réduire la réponse immunitaire dirigée contre un greffon chez le receveur, en traitant ce dernier par l'administration d'une dose de cellules stromales du foie ayant pour effet de réduire ou d'inhiber le rejet du greffon par l'hôte. L'invention concerne également une méthode permettant d'induire une réponse immunitaire affaiblie d'un tissu allogène contre un hôte, ou maladie du greffon contre l'hôte, par un traitement à base de cellules stromales du foie.

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