Liver tissue source

Details Liver tissue source Liver tissue source

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 35/407 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2397927

The instant invention provides, for the first time, the use of cadaveric organs from donors with non-beating hearts as a source of functional cells such as progenitor or stem cells for various medical purposes. More specifically, a method is disclosed whereby a tissue source of progenitor cells is obtained comprising harvesting tissue from a donor, wherein the donor has a non-beating heart for as long as about thirty hours postmortem and processing the cadaveric tissue to provide progenitor cells. The instant progenitors are used for various medical purposes as means of cell therapy, gene therapy, artificial organs, bioreactors, organ regeneration and the like.

L'invention concerne l'utilisation d'organes de cadavres de donneurs dont le coeur est arrêté, en tant que source de cellules fonctionnelles, telles que des cellules souches, à diverses fins médicales. L'invention concerne notamment un procédé permettant l'obtention d'un tissu source de cellules souches, qui consiste à prélever du tissu chez un donneur dont le coeur s'est arrêté postmortem depuis environ 30 heures, et à traiter le tissu de cadavre, de manière que des cellules souches soient produites. Les souches de l'invention sont utilisées à diverses fins médicales, comme moyen de thérapie génique, de thérapie cellulaire, comme organes artificiels, bioréacteurs, régénérateur d'organe et similaire.

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