C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 9/00 (2006.01) A61K 31/56 (2006.01)
Patent
CA 2446314
A compound of formula (I), wherein each of R1, R2, R3, R4, R4', R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally inserted with NH-, -N(alkyl)-, -O-, -S-, -SO-, -SO2-, -O-SO2-, -SO2- O-, -SO3-O-, -CO-, -CO-O-, -O-CO-, -CO-NR'-, or NR'-CO-; or R3 and R4 together, R4 and R5 together, R5 and R6 together, or R6 and R7 together are eliminated so that a C=C bond is formed between the carbons to which they are attached; each of R8, R9, R10, R13, and R14, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; n is 0, 1, or 2; A is alkylene, alkenylene, or alkynylene; and each of X, Y, and Z, independently, is alkyl, haloalkyl, -OR', -SR', -NR'R", -N(OR')R", or N(SR')R"; or X and Y together are =O, =S, or =NR'; wherein each of R' and R", independently, is hydrogen, alkyl, or haloalkyl.
L'invention concerne un composé de formule (I) dans laquelle dans chaque cas, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿11?, R¿12?, R¿15?, R¿16? et R¿17? désignent, indépendamment les uns des autres, hydrogène, halo, alkyle, haloalkyle, hydroxy, amino, carboxyle, oxo, acide sulfonique ou alkyle, éventuellement introduit conjointement avec NH-, -N(alkyle)-, -O-, -S-, -SO-, -SO¿2?-, -O-SO¿2?-, -SO¿2?-O-, -SO¿3?-O-, -CO-, -CO-O-, -O-CO-, -CO-NR'-, ou NR'-CO- ; ou R¿3? et R¿4? conjointement, R¿4? et R¿5? conjointement, R¿5? et R¿6? conjointement, ou R¿6? et R¿7? conjointement sont éliminés, de sorte à former une liaison C=C entre les carbones auxquels ils sont liés ; chacun des restes R¿8?, R¿9?, R¿10?, R¿13? et R¿14? désignent indépendamment les uns des autres, hydrogène, halo, alkyle, haloalkyle, hydroxyalkyle, alcoxy, hydroxy, ou amino ; n vaut 0, 1 ou 2 ; A désigne alkylène, alkénylène ou alkylnylène ; et chacun de X, Y et Z désigne indépendamment, alkyle, haloalkyle, -OR', -SR', -NR'R'', -N(OR')R'', ou N(SR')R'' ; ou X et Y désignent conjointement =O, =S ou =NR' ; chacun des restes R' et R'' désignant indépendamment l'un de l'autre, hydrogène, alkyle ou haloalkyle.
Dai Qing
Liao Shutsung
Song Ching
Gowling Lafleur Henderson Llp
The University Of Chicago
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