A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) C07K 7/06 (2006.01)
Patent
CA 2612522
A composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, and an opthalmically acceptable carrier, an antimicrobially effective preservative, a tonicity agent for providing the composition with an opthalmically acceptable tonicity, a comfort enhancing agent, at least one of an acidic or basic pH adjusting agent capable of adjusting pH of the composition to a desired ophthalmically acceptable pH level, and a buffer to substantially maintain the desired pH level.
L'invention concerne une composition comprenant un agent peptidique incluant une séquence d'amino-acides LKKTET ou LKKTNT, un variant conservateur de celui-ci ou un agent stimulant qui stimule la production d'un peptide LKKTET ou LKKTNT, ou un variant conservateur de celui-ci, et un excipient acceptable d'un point de vue ophtalmique, un conservateur efficace d'un point de vue antimicrobien, un agent de tonicité pour conférer à la composition une tonicité acceptable d'un point de vue ophtalmique, un agent améliorant le confort, au moins une partie d'un agent ajustant le pH acide ou basique et capable d'ajuster le pH de la composition à un taux du pH désiré, acceptable d'un point ophtalmique, et un tampon pour conserver substantiellement le taux désiré du pH.
Crockford David
Goldstein Allan L.
Hannappel Ewald
Sosne Gabriel
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Regenerx Biopharmaceuticals Inc.
Universitaet Erlangen-Nuernberg
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