C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2295604
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
La présente invention concerne un anticorps dirigé contre LO-CD2a ainsi que des procédés d'utilisation de tels anticorps ou molécules, lesquels se fixent sur le même épitope (ou sur une portion de celui-ci) afin d'empêcher ou d'inhiber une réponse immune chez l'homme, de préférence lorsque la réponse immune est induite par l'activation et la prolifération de lymphocytes T ou de cellules tueuses naturelles. L'administration à un patient d'une dose efficace de l'anticorps dirigé contre LO-CD2a va empêcher ou inhiber le rejet de greffon, la réaction du greffon contre l'hôte ou une maladie auto-immune.
Bazin Herve
Kaplan Ruth
Kieber-Emmons Thomas
Latinne Dominique
Postema Christina E.
Biotransplant Inc.
Smart & Biggar
Universite Catholique de Louvain
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