Local delivery of 17-beta estradiol decreases neointimal...

Details Local delivery of 17-beta estradiol decreases neointimal... Local delivery of 17-beta estradiol decreases neointimal...

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2300246

The cardioprotective effects of estrogen are well recognized. In in vitro experiments, and upon systemic administration, 17 - beta estradiol has shown to inhibit vascular smooth muscle cell proliferation and intimal hyperplasia. We hypothesized that locally delivered 17 - beta estradiol could inhibit neointimal proliferation following balloon angioplasty in porcine coronary arteries. Immunohistochemical, and morphometric analyses revealed that, arterial segments treated with local delivery of 17 - beta estradiol showed significantly less smooth muscle cell proliferation and neointima formation. Compared to PTCA only, or vehicle alone, 17 - beta estradiol decreased neointima formation by 54.6 % and 64.9 % respectively.

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