A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61P 41/00 (2006.01)
Patent
CA 2381031
The cardioprotective effects of estrogen are well recognized. In in vitro experiments, and upon systemic administra- tion, 17-beta estradiol has shown to inhibit vascular smooth muscle cell proliferation and intima hyperplasia and to improve vascular endothelium function, after vascular injury. We hypothesized that locally delivered 17-beta estradiol could prevent restenosis. Com- positions are use of 17-beta estradiol for in-situ administration at a vascular injured site are objects of the present invention.
Les effets cardioprotecteurs des oestrogènes sont connus de longue date. Or, il s'avère que dans des expériences <i>in vitro</i>, et par administration systémique, le 17-bêta estradiol inhibe la prolifération des cellules des muscles lisses vasculaires et l'hyperplasie intimale et renforce les fonctions de l'endothélium vasculaire, après une lésion vasculaire. Nous avions admis comme hypothèse que le 17-bêta estradiol administré localement pouvait empêcher la resténose. L'invention concerne donc des compositions renfermant du 17-bêta estradiol, ainsi que leur utilisation dans le cadre d'une administration <i>in-situ</i> au niveau d'un site vasculaire lésé.
Chandrasekar Baskaran
Tanguay Jean-Francois
Goudreau Gage Dubuc
Institut de Cardiologie de Montreal
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