Local drug delivery film, for periodontal treatment

Details Local drug delivery film, for periodontal treatment Local drug delivery film, for periodontal treatment

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 6/00 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 7/16 (1995.01)

Patent

CA 2143413

The present invention provides a local drug delivery film, which is characterized by comprising, as release control component, polymer mixture consisting of polycaprolactone having molecular weight of 30,000 - 60,000 and polycaprolactone having molecular weight less than 1,000 in a ratio of 1:1 - 4:1, and as active component, periodontal therapeutic agent. The present local drug delivery film is prepared by admixing homogeneously active component with melted polymer mixture and pressing into film. And the present drug delivery film has excellent sustained release pattern and excellent treatment effect in oral disease with release amount 1.7 mg which is 0.12 % of prescription amount, 1400 mg, for adults during 7 days and provides the application stability into human body.

L'invention concerne une pellicule libérant un médicament localement, caractérisée par le fait de contenir une composante pour la libération contrôlée, un mélange de polymères constitué de polycaprolactone ayant un poids moléculaire de 30 000 - 60 000 et de polycaprolactone ayant un poids moléculaire inférieur à 1 000 dans un rapport de 1:1 - 4:1 et, comme composante active, un agent thérapeutique périodontique. La pellicule est préparée en mélangeant la composante active avec le mélange de polymères fondus jusqu'à ce que le tout soit homogène et à presser le mélange pour obtenir une pellicule. Le mode de libération contrôlée par ce dispositif est excellent, de même que le traitement des maladies buccales avec une quantité libérée de 1,7 mg qui correspond à 0,12 % de la dose prescrite qui est de 1 400 mg pour un adulte pendant 7 jours. Le dispositif permet également une application stable du traitement dans le corps humain.

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