Local regional chemotherapy and radiotherapy using in situ...

A - Human Necessities – 61 – K

Patent

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A61K 47/42 (2006.01) A61K 9/10 (2006.01) A61K 9/16 (2006.01) A61K 45/08 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61K 51/12 (2006.01) A61M 36/00 (2006.01) A61N 5/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2432797

Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polymino acid, with a therapic agent, such as a radionuclide or a drug, and administering a cross-linking agent. The hydrogel/therapeutic agent composition is retained in the tumor for safe and efficient tumor therapy. Alternatively, a hydrogel composition is generated in situ in an artery which nourishes a tumor to occlude the artery.

L'invention concerne des procédés relatifs au traitement régional local in situ d'un sujet, par exemple pour une tumeur. Une composition d'hydrogel est produite in situ dans la tumeur par administration d'un polymère, tel qu'un polysaccharide ou un polyamino-acide, avec un agent thérapeutique, tel qu'un radionucléide ou une substance médicamenteuse, et par administration d'un agent de réticulation. La composition hydrogel/agent thérapeutique est retenue dans la tumeur de façon à permettre une thérapie antitumorale sûre et efficace. Dans une variante, une composition d'hydrogel est produite in situ dans une artère nourrissant une tumeur de façon à occlure ladite artère.

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