Local treatment of bone defects with matrix releasing bmp or...

Details Local treatment of bone defects with matrix releasing bmp or... Local treatment of bone defects with matrix releasing bmp or...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 38/29 (2006.01) A61L 24/00 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2592877

A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferably formed in the absence of a growth factor. The matrix may be used in the treatment of fluid-filled cysts such as Tarlov cysts, ovarian cysts, arachnoid cysts, aneurysmal bone cysts or hepatic cysts.

L'invention concerne un procédé de traitement local de déficit osseux spécifiques, tels que l'ostéoporose ou des kystes osseux, comprenant une étape d'administration locale d'une formulation comprenant un peptide de fusion contenant un premier domaine comprenant la PTH, la BMP2 ou la BMP7, et un second domaine comprenant un domaine de substrat réticulable de manière covalente ; et un matériau permettant de former une matrice biodégradable conçue pour la croissance ou croissance en cours cellulaire, le peptide de fusion est relié de manière covalente à la matrice. Dans un mode de réalisation, la matrice contient un ou plusieurs agents de contraste, et elle est, de préférence, formée en l'absence d'un facteur de croissance. La matrice peut être utilisée dans le traitement de kystes remplis de liquide, tels que les kystes de Tarlov, des kystes ovariens, des kystes arachnoïdiens, des kystes anévrismaux des os ou des kystes hépatiques.

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