Local vascular delivery of mycophenolic acid in combination...

A - Human Necessities – 61 – L

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A61L 27/44 (2006.01) A61K 31/343 (2006.01) A61K 31/365 (2006.01) A61K 31/436 (2006.01) A61L 27/14 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2493423

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

Les dispositifs médicaux, en particulier les dispositifs médicaux implantables, peuvent être enrobés afin de réduire ou d'éliminer considérablement la réaction de l'organisme biologique engendrée par l'insertion de ce dispositif. Les dispositifs peuvent être enrobés de plusieurs types de matières biocompatibles. Des agents thérapeutiques, des agents ou des composés peuvent être mélangés aux matières biocompatibles et fixées sur au moins une partie du dispositif. Ces médicaments, agents ou composés peuvent aussi réduire la réaction de l'organisme biologique induite par l'insertion du dispositif. En outre, ces agents thérapeutiques, agents et/ou composés peuvent favoriser la guérison, y compris la formation de caillots sanguins. Aussi, ces dispositifs peuvent être modifés pour favoriser l'endothélisation. On peut faire appel à diverses matières et méthodes d'enrobage pour fixer les médicaments, agents ou composés sur le dispositif médical jusqu'à sa mise en place. Par ailleurs, les instruments utilisés pour placer les dispositifs implantables peuvent être modifiés pour diminuer le risque de bris du dispositif à implanter durant le déploiement. Ces dispositifs comprennent les endoprothèses, les greffons, les dispositifs d'anastomose, les manchons périvasculaires, les sutures et les agrafes. En outre, diverses combinaisons de polymères peuvent être utilisées pour réguler la vitesse d'élution des médicaments, agents et/ou composés hors des dispositifs médicaux implantables.

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