Localized oligonucleotide therapy

Details Localized oligonucleotide therapy Localized oligonucleotide therapy

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01) A61M 37/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082411

- 48 - LOCALIZED OLIGONUCLEOTIDE THERAPY Abstract of the Disclosure Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. The antisense oligonucleotides are applied directly to the desired locus of the cells to be treated, where they hybridize with the mRNA and inhibit expression of the gene. Devices for localized antisense application and methods for making them also are described. 188PAC5473/3.AE8

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