Localized therapy of lower airways inflammatory disorders...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) A61K 9/72 (2006.01) A61K 31/7088 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 11/00 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2660519

The present invention is drawn to methods and compositions for treating inflammatory disorders of the lower airways, comprising administering an effective amount of an agent, which modulates the expression and/or activity of a proinflammatory cytokine or fragment thereof), preferably in a human. The proinflammatory cytokine contemplated by the invention includes IL-1, 1L-6, IL-8 and TNF-alpha. The present invention describes a kit comprising a delivery device and a pharmaceutical composition for administration of the agent. The pharmaceutical composition includes at least one proinflammatory cytokine inhibitor, optionally one or more additional active ingredients, and at least one pharmaceutically active carrier. The delivery device further comprises a nebulizer, an inhaler, a powder dispenser, an intrapulmonary aerosol izer and a sub-miniature aerosolizer.

La présente invention concerne des procédés et des compositions permettant de traiter des troubles inflammatoires des voies aériennes inférieures, les procédés consistant à administrer une quantité efficace d'un agent qui module l'expression et/ou l'activité d'une cytokine proinflammatoire ou d'un fragment de celle-ci, de préférence chez un être humain. La cytokine proinflammatoire faisant l'objet de l'invention inclut les IL-1, IL-6, IL-8 et TNF-alpha. La présente invention concerne une trousse contenant un dispositif de distribution et une composition pharmaceutique permettant d'administrer l'agent. La composition pharmaceutique inclut au moins un inhibiteur de cytokine proinflammatoire, éventuellement un ou plusieurs principes actifs supplémentaires, et au moins un support pharmaceutiquement actif. Le dispositif de distribution comporte en outre un nébuliseur, un inhalateur, un distributeur de poudre, un pulvérisateur intrapulmonaire et un pulvérisateur sous-miniature.

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