Locally administrable, biodegradable and sustained-release...

A - Human Necessities – 61 – K

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Details

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/52 (2006.01) A61K 9/70 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2253980

This invention relates to locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof, which can show continuous drug effect for a long time by controlling the release time and by making the drug remain in the periodontal pocket for a prolonged time. The composition is prepared by i) making a microsphere containing the physiologically active substance, ii) making the mixture of the microspheres and water-soluble polymer such as polysaccharides, iii) making the mixture into the form of film or strip or/and iv) coating the film or strip with a ration aqueous solution such as calcium and barium. The present pharmaceutical composition can be easily administered using forceps, has minimized side effects and maximizes the effect by releasing the active substance at the minimum dose, and makes the patients feel comfortable.

Cette invention concerne une composition à administration locale, biodégradable et à libération prolongée, destinée à être utilisée dans le traitement de la desmodontite, et son procédé de préparation. Ce médicament peut avoir un effet continu et de longue durée lorsqu'on régule son temps de libération et qu'on le maintient dans la poche périodontique sur une durée prolongée. La préparation de cette composition se caractérise par i) l'élaboration des microsphères contenant la substance physiologiquement active, ii) la formation du mélange des microsphères et du polymère soluble dans l'eau tel que des polysaccharides, iii) la transformation du mélange en film ou bande et/ou iv) l'application du film ou bande avec une solution aqueuse cationique telle que le calcium et le barium. Cette composition peut être facilement administrée à l'aide de pinces, ses effets secondaires peuvent être réduits et l'effet de libération de la substance active, en dose minimale, accru, ce qui permet aux patients de se sentir plus à l'aise.

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