Long-acting dna dendrimers and methods thereof

Details Long-acting dna dendrimers and methods thereof Long-acting dna dendrimers and methods thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2731521

This invention provides a unique composition which includes a DNA dendrimer combined with siRNA molecule. Further, methods of preparing a composition which includes a DNA dendrimer combined with a siRNA molecule, methods of protecting a DNA dendrimer siRNA complex against degradation in body fluids, methods of protecting a DNA dendrimer against degradation in bodily fluids, and methods of delivering a DNA dendrimer into bodily fluids are provided.

L'invention concerne une composition unique qui comprend un dendrimère d'ADN combiné à une molécule d'ARNsi. En outre, des procédés de préparation d'une composition qui comprend un dendrimère d'ADN combiné à une molécule d'ARNsi, des procédés de protection d'un complexe d'ARNsi de dendrimère d'ADN contre une dégradation dans des liquides organiques, des procédés de protection d'un dendrimère d'ADN contre une dégradation dans des liquides organiques et des procédés de distribution d'un dendrimère d'ADN dans des liquides organiques sont fournis.

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