Long-acting glp-1 derivatives, and methods of treating...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2726903

La présente invention porte d'une manière générale sur des analogues polypeptidiques du GLP-1 (9-34) et du GLP-1 (9-36) qui ont des demi-vies in vivo accrues résultant d'une susceptibilité réduite à des enzymes protéolytiques. D'autres aspects de l'invention portent sur des procédés d'utilisation des analogues polypeptidiques décrits ici pour traiter un dysfonctionnement cardiaque et d'autres maladies liées au cur. Encore un autre aspect de la présente invention porte sur des formulations comprenant les analogues polypeptidiques décrits ici.

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