Long acting injectable formulations containing hydrogenated...

Details Long acting injectable formulations containing hydrogenated... Long acting injectable formulations containing hydrogenated...

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 31/365 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) A61K 47/14 (2006.01) A61K 47/44 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2312898

This invention relates to novel, long-acting injectable formulations. These formulations comprise: (a) a therapeutic agent selected from the group consisting of, e.g., insecticides, acaricides, parasiticides, growth enhancers and oil-soluble NASIDS; (b) hydrogenated castor oil and (c) a hydrophobic carrier comprising: (i) triacetin, benzyl benzoate or ethyl oleate or a combination thereof; and (ii) acylated monoglycerides, propyl dicaprylates/dicaprates or caprylic/capric acid triglycerides or a combination thereof. Also provided herein is a method for the treatment or prevention of various disease states by the parental administration of the invention formulations.

L'invention concerne de nouvelles formulations injectables à action prolongée qui renferment a) un agent thérapeutique sélectionné dans le groupe constitué d'insecticides comme par exemple des acaricides, parasiticides, activateurs de croissance et NASIDS oléosolubles, b) d'huile de ricin hydrogénée et c) d'un support hydrophobe comprenant i) de la triacétine, du benzoate de benzyle ou de l'oléate d'éthyle ou une combinaison de ceux-ci et ii) des monoglycérides acylés, des dicaprylate/dicaprates de propyle ou des triglycérides d'acide caprylique/caprique ou une combinaison de ceux-ci. Fait aussi l'objet de cette invention un procédé pour le traitement ou la prévention de différentes maladies par l'administration par voie parentérale des formulations décrites.

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