Long acting injectable formulations containing hydrogenated...

Details Long acting injectable formulations containing hydrogenated... Long acting injectable formulations containing hydrogenated...

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61K 47/44 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2079255

F2 119/DLR62 18485 TITLE OF THE INVENTION LONG ACTING INJECTABLE FORMULATIONS CONTAINING HYDROGENATED CASTOR OIL ABSTRACT OF THE DISCLOSURE There is disclosed an injectable formulation containing hydrogenated castor oil and an avermectin compound which has been discovered to provide an unexpectedly long duration of activity. The formulation contains the avermectin active ingredient and a suitable amount of hydrogenated castor oil in a physiologically acceptable hydrophobic non-aqueous vehicle. Efficacious levels of the avermectin compounds have been maintained for up to 42 days. Prior injectable formulations provided only 14 days duration of activity, or had other undesirable side effects such as pain and tissue irritation at the injection site.

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