Long acting injectable parasiticidal formulations

Details Long acting injectable parasiticidal formulations Long acting injectable parasiticidal formulations

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 47/08 (2006.01) A61K 47/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2619601

This application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associated with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

L'invention concerne des formulations injectables à action prolongée (LAI) destinées à combattre des ectoparasites et des endoparasites chez des mammifères. Particulièrement, cette invention concerne une formulation LAI contenant un solvant volatil sous-cutané, un polymère acceptable sur le plan biologique, des agents bioactifs et éventuellement un ou plusieurs excipients ou additifs acceptables sur le plan anti-ectoparasitique ou anti-endoparasitique. Singulièrement, les formulations injectables liquides à action prolongée de l'invention résolvent les problèmes associés aux formulations injectables de l'art antérieur en ce qu'elles possèdent une stabilité à long terme, permettant d'incommoder des aiguilles de plus petit diamètre et de produire des effets de longue durée dans la lutte contre les parasites chez des mammifères. Les formulations uniques de l'invention permettent également de combattre des ectoparasites et des endoparasites devenus résistants aux antibiotiques macrolides.

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