Long-acting polymeric prodrugs of exendin

Details Long-acting polymeric prodrugs of exendin Long-acting polymeric prodrugs of exendin

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/26 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 25/28 (2006.01) C07K 14/605 (2006.01)

Patent

CA 2689909

Long-acting polymer exendin-4 or exendin agonist derivatives of the formula Pol-L-E are provided wherein Pol is a polymer, L is a releasing linker undergoing slow autohydrolysis and E is an exendin or exendin agonist. Theseexendin or exendin agonists are slowly released from Pol-L upon administration to a living organism. The derivatives are useful e.g. for the treatment of diabetes mellitus.

L'invention concerne l'exendine 4 polymère longue durée ou des dérivés d'agonistes de l'exendine représentés par la formule Pol-L-E, dans laquelle Pol est un polymère, L est un liant de libération subissant une autohydrolyse lente et E est une exendine ou un agoniste de l'exendine. Cette exendine ou ces agonistes de l'exendine sont libérés lentement à partir de Pol-L lors de l'administration à un organisme vivant. Les dérivés sont utiles, par exemple, pour le traitement du diabète sucré.

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