C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/246, 260/355
C07C 55/28 (2006.01) C07C 55/32 (2006.01) C07C 57/13 (2006.01) C07C 57/30 (2006.01) C07C 57/34 (2006.01) C07C 57/38 (2006.01) C07C 57/42 (2006.01) C07C 59/245 (2006.01) C07C 59/305 (2006.01) C07C 59/84 (2006.01) C07C 69/616 (2006.01)
Patent
CA 1262552
ABSTRACT Long-chain .alpha.,.omega.-dicarboxylic acids of formula I' Image I' and in vivo hydrolyzable functional derivatives of the carboxylic groups thereof, wherein R1 and R2 each independently represents lower alkyl; lower alkyl substituted by hydroxy, lower alkoxy, halogen or phenyl which may be substituted one or more times by hydroxy, lower alkoxy, lower alkyl or halogen; lower alkenyl; lower alkynyl; C3 - C7 cycloalkyl; phenyl or phenyl substituted by hydroxy, halogen, lower alkyl or lower alkoxy; X and Y indepen- dently represents hydrogen, lower alkyl, lower alkoxy, cyano, halogen carboxyl, lower alkoxy-carbonyl, carbamoyl or hydroxy and Q represents a linear, satu- rated or unsaturated alkylene chain of 8 to 14 carbon atoms which may be - (a) substituted by oxygen, halogen, hydroxy or lower alkoxy, (b) interrupted by one or more heteroatoms and/or (c) of which 1 - 4 chain members may be part of a C3 - C7 cycloalkyl or phenyl ring pro- vided that when Q represents a linear saturated alkylene chain of 8 to 14 carbon atoms, R1 and R2 represents methyl and Y hydrogen, then X is not hydrogen, ethoxycarbonyl, bromo, cyano or methyl or when R1 and R2 represents methyl, X and Y are hydrogen, then Q is not the group Image provide a significant lipid-lowering effect as well as an antidiabetic effect.
484907
Bar-Tana Jacob
Hagenbruch Bernd
Pill Johannes
Stegmeier Karlheinz
Witte Ernst-Christian
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Syndromex Ltd.
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