Long-chain fatty acyl elongase inhibitor comprising...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/48 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/197 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/4155 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/437 (2006.01) A61K 31/439 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/4965 (2006.01) A61K 31/4985 (2006.01) A61K 31/4995 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5375 (2006.01

Patent

CA 2722075

[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. [Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): (see formula I) [wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].

L'invention porte sur un composé utile en tant qu'agent prophylactique ou thérapeutique pour des maladies cardiovasculaires, des maladies du système nerveux, des maladies métaboliques, des maladies génitales, des maladies gastro-intestinales, un néoplasme, des maladies infectieuses et autres, ou en tant qu'herbicide. De façon spécifique, l'invention porte sur un inhibiteur d'enzyme d'allongement d'acide gras à longue chaîne incluant un composé représenté par la formule (I) [dans laquelle W représente un atome d'hydrogène, un alkyle en C1-6 ou similaire ; X représente un aryle, un hétéroaryle ou similaire ; n représente un chiffre égal à 0 ou 1 ; Z représente un atome d'hydrogène, un alkyle en C1-6 ou similaire ; et A1, A2, A3 et A4 représentent indépendamment CH ou N] ou un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif.

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