C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/96 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) C12N 9/18 (2006.01)
Patent
CA 2659809
The present invention provides for butyrylcholinesterase (BChE) attached to polyethylene glycol (PEG) to form a complex having greatly increased mean residence time (MRT) in the system of an animal following injection thereinto. Also disclosed are compositions of such complexes, methods of preparing these complexes and method for using these complexes and compositions in the treatment and/or prevention of toxic effects of poisons, such as neurotoxins, to which said animals, such as humans, have been, or may become, exposed.
La présente invention concerne une butyrylcholinestérase (BChE) fixée à un polyéthylène glycol (PEG) pour former un complexe ayant une durée de séjour moyenne (Mean Residence Time, MRT) très prolongée dans le système d'un animal après qu'il a été injecté dans celui-ci. L'invention concerne également des compositions de tels complexes, des procédés de préparation de ces complexes et un procédé d'utilisation de ces complexes et de ces compositions pour le traitement et/ou la prévention des effets toxiques de poisons, tels que des neurotoxines, auxquels lesdits animaux, tels que des humains, ont été ou peuvent devenir exposés.
Huang Yue
Wilgus Harvey
Pharmathene Inc.
Smart & Biggar
LandOfFree
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