Long lasting fusion peptide inhibitors of viral infection

Details Long lasting fusion peptide inhibitors of viral infection Long lasting fusion peptide inhibitors of viral infection

C - Chemistry, Metallurgy

07

K

C07K 14/115 (2006.01) A61K 38/16 (2006.01) A61P 31/12 (2006.01) C07K 14/135 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2372338

Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.

L'invention concerne des peptides qui ont une activité antivirale et anti-fusogène, et qui ont été modifiés de manière à présenter une stabilité accrue et une demi-vie améliorée in vivo. Les peptides sélectionnés comprennent les inhibiteurs de fusion DP178 et DP107 ainsi que des peptides associés et des analogues de ceux-ci. Ces peptides modifiés sont capables de former des liaisons covalentes avec un ou plusieurs constituants du sang, de préférence avec un constituant sanguin mobile.

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