Long lasting insulin derivatives and methods thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07K 1/113 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2526957

The present invention relates to an insulin derivative comprising an insulin molecule and a reactive group for covalently bonding a blood component, wherein preferably the insulin molecule is human natural insulin molecule and the reactive group is coupled to an amino acid of the insulin molecule at a position selected from the positions Gly A1, Phe B1 and Lys B29.

L'invention concerne un dérivé de l'insuline comprenant une molécule d'insuline et un groupe réactif pour la liaison covalente d'un élément sanguin. Cette molécule d'insuline est de préférence une molécule d'insuline humaine naturelle et le groupe réactif est couplé à un acide aminé de la molécule d'insuline en une position sélectionnée parmi les positions Gly A1, Phe B1 et Lys B29.

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