Long lasting natriuretic peptide derivatives

Details Long lasting natriuretic peptide derivatives Long lasting natriuretic peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/58 (2006.01) A61K 38/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2488348

This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardio- vascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.

L'invention concerne des dérivés de peptide natriurétique (NP) de longue durée. Le dérivé NP comprend un peptide NP et une entité réactive couplée au peptide NP. L'entité réactive peut se lier par covalence avec une fonctionnalité sur un composant sanguin. D'une manière plus spécifique, l'invention concerne des dérivés NP ayant une demi-vie in vivo prolongée ainsi qu'une méthode de traitement des maladies et des troubles cardio-vasculaires, tels que l'insuffisance cardiaque globale décompensée aiguë et l'insuffisance cardiaque globale chronique.

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