Long-lasting release nifedipine preparation

Details Long-lasting release nifedipine preparation Long-lasting release nifedipine preparation

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 9/24 (2006.01) A61K 9/30 (2006.01) A61K 31/4422 (2006.01)

Patent

CA 2191178

This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%.

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