Long qt genes and method for diagnosing or preventing the...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/12 (2006.01) A61K 33/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2214646

The invention relates to the identification of the molecular basis of acquired long QT syndrome. More specifically, the invention has identified that HERG is associated with acquired long QT syndrome. HERG has been identified to encode the major subunit for the IKr channel. It has been found that increasing the extracellular levels of K+ paradoxically increases the outward current of this channel. Increasing extrarcellular K+ levels in patients, especially those being treated with antiarrhythmic medication or other medication which can cause cardiac arrhythmia or those with the hereditary form of long QT syndrome, decreases the likelihood of developing LQT and torsade de pointes.

L'invention porte sur l'identification du fondement moléculaire du syndrome du QT long acquis. Plus précisément, l'invention a établi que le gène HERG est associé au syndrome du QT long. On a démontré que HERG encode la principale sous-unité du canal 1Kr. On a découvert que le fait d'accroître les concentrations extracellulaires de K+ a pour effet paradoxal d'augmenter le courant centrifuge de ce canal. Le fait d'augmenter les concentration extracellulaires de potassium chez les patients, en particulier chez ceux qui reçoivent des antiarythmiques ou d'autres médicaments qui peuvent induire une arythmie cardiaque ou chez ceux qui sont atteints de la forme héréditaire du syndrome du QT long, a pour effet de réduire la probabilité de développer un syndrome du QT long et des torsades de pointe.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Long qt genes and method for diagnosing or preventing the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Long qt genes and method for diagnosing or preventing the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Long qt genes and method for diagnosing or preventing the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1489510

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.