Long-term delivery device including loading dose

Details Long-term delivery device including loading dose Long-term delivery device including loading dose

A - Human Necessities

61

K

167/164

A61K 9/00 (2006.01)

Patent

CA 2032923

The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery means) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery means) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (A) a loading dose chamber (30) and retaining means (16) retaining a loading dose (32) (short-term delivery means) for rapid and continuous delivery of agent to the environment of use; and (B) a long-term dispensing device (12) (long-term delivery means) comprising a semipermeable wall (14) which surrounds and defines an internal lumen (20), a driving source (22) (expansion means) in the lumen for expanding and occupying an increased volume of the lumen, a beneficial agent (24) in the lumen that provides a dispensable formulation to the environment of use, and an exit (28) in the device for delivery of the beneficial agent to the environment of use over time. A densifier (26) and/or a moveable barrier means (34) may also be included in the lumen of the long-term dispensing device.

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