Long term storage of red cells in unfrozen solution

A - Human Necessities – 01 – N

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A01N 1/02 (2006.01) A61K 35/18 (2006.01)

Patent

CA 2216251

A method for prolonging storage shelf-life of red blood cells under refrigerated conditions includes separating plasma from the red blood cells while retaining residual plasma and adding a biologically compatible solution having an effective osmolality of less than 70 mOsm to the red blood cells. The biologically compatible solution preferably includes at least one penetrating solute that penetrates red cells more slowly than water and substantially no non-penetrating anions and non-penetrating non-electrolytes.

L'invention porte sur un procédé permettant de prolonger la durée de stockage de globules rouges réfrigérés consistant à séparer le plasma d'avec les globules rouges, à conserver le plasma résiduel, à ajouter aux globules rouges une solution à compatibilité biologique présentant une osmolalité efficace de moins de 70 mOsm vis à vis des globules rouges et comprenant au moins un soluté pénétrant les globules rouges plus lentement que l'eau, et sensiblement exempt d'anions non pénétrants et de non électrolytes non pénétrants.

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