Long wap promoter for mammary expression of human protein c

Details Long wap promoter for mammary expression of human protein c Long wap promoter for mammary expression of human protein c

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2144333

Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic ani- mals that incorporate DNAs according to the present invention. Transgenic animals of the present invention are produced by in- troducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature animal and inherited in normal, mendelian fashion. Particularly efficient expression was accomplished using a long whey acidic protein promoter and genomic protein C.

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