Loss of imprinting-based in vitro diagnostic method to...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2276306

Compositions and methods for the diagnosis and treatment of diseases that are associated with imprinting are provided. Such compositions and methods are useful in restoring a normal pattern of imprinting to cells. The compositions comprise pharmacological agents that are involved in imprinting and can be used in preventive and therapeutic methods to restore a normal pattern of imprinting. Such agents are capable of restoring a normal pattern of imprinting to cells. Further methods of the invention include means for identifying pharmacological compounds that exert their effect by restoring normal imprinting to abnormally imprinted chromosomes and genes. Additionally, the invention could also be used to identify new compounds that exert their effect by restoration of normal imprinting to diseased tissues that exhibit underlying abnormal imprinting.

La présente invention concerne des compositions et procédés servant au diagnostic et au traitement de maladies qui sont associées à l'empreinte génomique. De telles compositions sont utilisées pour rétablir un modèle d'empreinte normal de cellules. Les compositions comportent des agents pharmacologiques qui sont associés à l'empreinte et qui peuvent être utilisés dans des procédés préventifs et thérapeutiques en vue de rétablir un modèle d'empreinte normal de cellules. De tels agents sont susceptibles de rétablir un modèle d'empreinte normal de cellules. D'autres procédés de l'invention concernent des éléments d'identification de composés pharmacologiques qui ont pour effet de rétablir une empreinte normale sur des chromosomes et gènes dont les empreintes sont anormales. De plus, l'invention pourrait également être utilisée afin d'identifier de nouveaux composés qui ont pour effet de rétablir une empreinte normale sur des tissus malades qui présentent une empreinte anormale sous-jacente.

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