Lovastatin compositions derived from red rice fermentation...

Details Lovastatin compositions derived from red rice fermentation... Lovastatin compositions derived from red rice fermentation...

A - Human Necessities

61

K

A61K 31/366 (2006.01) A23L 1/28 (2006.01) A23L 1/30 (2006.01) A61K 36/062 (2006.01) A61P 3/06 (2006.01) C12N 1/14 (2006.01) C12P 1/02 (2006.01)

Patent

CA 2309100

Methods and compositions are disclosed which comprise lovastatin-comprising red rice fermentation products, that can be used as natural dietary supplements and/or medicaments for the treatment or prevention of hyperlipidemia and associated disorders and symptoms, such as cardiovascular diseases, cerebrovascular diseases, diabetes, hypertension, obesity, asthenic breathing, chronic headache, chest pain and tightness, limb swelling and distention, loss of appetite and excess expectoration. The methods and compositions are effective in lowering both the serum cholesterol and serum triglyceride levels in humans, and can be used for maintaining cardiovascular health. The invention also encompasses particular Monascus strains that yield fermentation products with the desired biological activities.

L'invention concerne des compositions qui contiennent des produits fermentés à base de riz rouge et des procédés associés. Ces compositions peuvent être utilisées comme compléments alimentaires naturels et/ou médicaments pour le traitement ou la prévention de l'hyperlipidémie et des troubles et symptômes associés, tels que les maladies cardiovasculaires, les maladies cérébrovasculaires, le diabète, l'hypertension, l'obésité, la respiration asthénique, la céphalée chronique, les douleurs et l'oppression thoraciques, la tuméfaction et la distension des membres, la perte d'appétit et l'expectoration excessive. Ces procédés et ces compositions sont efficaces dans l'abaissement des taux de cholestérol sérique et de triglycéride sérique chez l'être humain, et peuvent être utilisés pour maintenir le système cardiovasculaire en bonne santé. L'invention concerne également des souches particulières de Monascus qui donnent des produits fermentés présentant les activités biologiques désirées.

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