Low burst poly-(lactide/glycolide) and methods to produce...

Details Low burst poly-(lactide/glycolide) and methods to produce... Low burst poly-(lactide/glycolide) and methods to produce...

C - Chemistry, Metallurgy

08

G

C08G 63/664 (2006.01)

Patent

CA 2678350

A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced "initial burst" effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.

L'invention concerne un matériau copolymère de PLG, appelé matériau de copolymère de PLG(p), conçu pour une utilisation dans une formulation à libération contrôlée pour un matériau bioactif, la formulation présentant un effet de libération immédiate ("initial burst") réduit lorsqu'elle est introduite dans le tissu d'un patient qui la nécessite. Un procédé de préparation du matériau de copolymère de PLG est également prévu, ainsi que des procédés d'utilisation.

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