Low-calcemic oxime analogs of 1.alpha.,25-dihydroxy vitamin d3

Details Low-calcemic oxime analogs of 1.alpha.,25-dihydroxy vitamin d3 Low-calcemic oxime analogs of 1.alpha.,25-dihydroxy vitamin d3

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/593 (2006.01) A61P 3/14 (2006.01)

Patent

CA 2463505

The present invention provides novel 16-ene-C25-oxime and 16-ene-C-25-oxime ether analogs of 1.alpha.,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compound of Formula I are useful for treating diseases which benefit from a modulation of the levels of 1.alpha.,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.

La présente invention concerne des nouveaux analogues éther 16-ene-C25-oxime et 16-ene-C-25-oxime de 1.alpha.,25-dihydroxy vitamine D¿3?, des compositions comprenant ces composés et des méthodes permettant d'utiliser ces composés en tant qu'inhibiteurs de CYP24. En particulier, le composé représenté par la formule I est utilisé pour traiter des maladies bénéficiant d'une modulation des niveaux de 1.alpha.,25-dihydroxy vitamine D¿3?, par exemple, des troubles de prolifération cellulaire.

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