Low dose dry pharmaceutical preparations

Details Low dose dry pharmaceutical preparations Low dose dry pharmaceutical preparations

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61J 3/06 (2006.01) A61K 9/20 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2062428

Disclosed are dry pharmaceutical preparations con- taining potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a demixing poten- tial of less than 10% for said agent. Such excipients include spray-dried polyalcohols, granulated .alpha.-lactose monohydrate, or mixtures thereof. Also disclosed is a process of manufacturing stable tablets containing nearly identical amounts of at least one steroidal medicinal agent present in each tablet in an amount varying from 0.005 to 0.5 percent by weight of the tablet. Also disclosed is a dry mix consisting essen- tially of 1 to 100 parts, by weight, of at least one medicinal agent uniformly distributed throughout 2000 to 20,000 parts, by weight, of the described excipients. The mixture can be used to make dry dosage forms such as capsules, tablets, powders, and slugged granulates.

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