Low dose ifn-gamma for treatment of disease

Details Low dose ifn-gamma for treatment of disease Low dose ifn-gamma for treatment of disease

A - Human Necessities

61

K

A61K 38/21 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) A61K 49/00 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2388005

The use of low doses of IFN-gamma in the treatment of interferon-sensitive diseases is described. The IFN-gamma can be administered orally, preferably buccally or sublingually, or parenterally in low doses to activate monocyte, neutrophil, or B cell function, to decrease acute inflammation, or to treat cancer, bacterial or fungal diseases, or fibrosis in a patient suffering from such disease states. Pharmaceutical formulations containing low doses of IFN- gamma in combination with a pharmaceutical acceptable carrier and suitable for oral administration are also described.

L'invention concerne à l'utilisation de IFN-gamma à faibles dosés, qui est destinée à traiter des maladies à sensibilité aux interférons. L'IFN-gamma peut être administré à faibles doses oralement, de préférence par voie buccale ou sublinguale, ou par voie parentérale pour activer la fonction des monocytes, des neutrophiles ou des cellules B afin de soigner une inflammation aiguë ou pour traiter le cancer, des maladies fongiques ou bactériennes ou encore la fibrose chez un patient souffrant de ces états pathologiques. L'invention concerne aussi des formulations pharmaceutiques contenant de faibles doses de IFN-gamma en combinaison avec un excipient pharmaceutiquement acceptable et conçues pour l'administration orale.

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